Dr Karen MacKenzie
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Publications related to this Person
Book Chapters
Mackenzie KL; Maritz, M.F. ; Richards LA, 2013, 'Assessment and quantification of telomerase enzyme activity', in Galluzzi L; Vitale I; Kepp O; Kroemer G (ed.), Cell Senescence: Methods and Protocols. Methods in Molecular Biology., Humana Press, New York, pp. 215 - 231, http://dx.doi.org/10.1007/978-1-62703-239-1
Maritz MF; Richards LA; MacKenzie KL, 2013, 'Assessment and Quantification of Telomerase Enzyme Activity', in Methods in Molecular Biology, Humana Press, pp. 215 - 231, http://dx.doi.org/10.1007/978-1-62703-239-1_14
Yuan J; Schuller C; Wen VW; Mackenzie KL, 2008, 'Molecular mechanisms that regulate the replicative lifespan of endothelial cells', in Cell Apoptosis Research Progress, edn. Original, Nova Publishers Inc, Hauppauge, New York, pp. 83 - 111
Moore MAA; MacKenzie KL, 1999, 'Optimizing conditions for gene transfer into human hematopoietic cells In: Marrow protection, Transduction of hematopoietic cells with drug resistance genes, Prog. Exp. Tum. Res.', in Marrow protection, Transduction of hematopoietic cells with drug resistance genes, Karger Publications, Basel, Switzerland, pp. 20 - 49
Journal articles
Fordham AM; Xie J; Gifford AJ; Wadham C; Morgan LT; Mould EVA; Fadia M; Zhai L; Massudi H; Ali ZS; Marshall GM; Lukeis RE; Fletcher JI; MacKenzie KL; Trahair TN, 2020, 'CD30 and ALK combination therapy has high therapeutic potency in RANBP2-ALK-rearranged epithelioid inflammatory myofibroblastic sarcoma', British Journal of Cancer, vol. 123, pp. 1101 - 1113, http://dx.doi.org/10.1038/s41416-020-0996-2
Reddel RR; MacKenzie KL; Bryan TM, 2020, 'End Products of Telomere Research', Cell Stem Cell, vol. 26, pp. 804 - 805, http://dx.doi.org/10.1016/j.stem.2020.05.006
Richards LA; Kumari A; Knezevic K; Thoms JAI; von Jonquieres G; Napier CE; Ali Z; O'Brien R; Marks-Bluth J; Maritz MF; Pickett HA; Morris J; Pimanda JE; MacKenzie KL, 2020, 'DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts', Haematologica, vol. 105, pp. 1517 - 1526, http://dx.doi.org/10.3324/haematol.2018.215699
Perera ON; Sobinoff AP; Teber ET; Harman A; Maritz MF; Yang SF; Pickett HA; Cesare AJ; Arthur JW; MacKenzie KL; Bryan TM, 2019, 'Telomerase promotes formation of a telomere protective complex in cancer cells', Science Advances, vol. 5, http://dx.doi.org/10.1126/sciadv.aav4409
Trahair T; Gifford AJ; Fordham A; Mayoh C; Fadia M; Lukeis R; Wood AC; Valvi S; Walker RD; Blackburn J; Heyer EE; Mercer TR; Barbaric D; Marshall GM; MacKenzie KL, 2019, 'Crizotinib and surgery for long-term disease control in children and adolescents with ALK-positive inflammatory myofibroblastic tumors', JCO Precision Oncology, vol. 3, pp. 1 - 11, http://dx.doi.org/10.1200/PO.18.00297
Berger AC; Korkut A; Kanchi RS; Hegde AM; Lenoir W; Liu W; Liu Y; Fan H; Shen H; Ravikumar V; Rao A; Schultz A; Li X; Sumazin P; Williams C; Mestdagh P; Gunaratne PH; Yau C; Bowlby R; Robertson AG; Tiezzi DG; Wang C; Cherniack AD; Godwin AK; Kuderer NM; Rader JS; Zuna RE; Sood AK; Lazar AJ; Ojesina AI; Adebamowo C; Adebamowo SN; Baggerly KA; Chen TW; Chiu HS; Lefever S; Liu L; MacKenzie K; Orsulic S; Roszik J; Shelley CS; Song Q; Vellano CP; Wentzensen N; Caesar-Johnson SJ; Demchok JA; Felau I; Kasapi M; Ferguson ML; Hutter CM; Sofia HJ; Tarnuzzer R; Wang Z; Yang L; Zenklusen JC; Zhang J; Chudamani S; Liu J; Lolla L; Naresh R; Pihl T; Sun Q; Wan Y; Wu Y; Cho J; DeFreitas T; Frazer S; Gehlenborg N; Getz G; Heiman DI; Kim J; Lawrence MS; Lin P; Meier S; Noble MS; Saksena G; Voet D; Zhang H; Bernard B; Chambwe N; Dhankani V; Knijnenburg T; Kramer R; Leinonen K; Miller M; Reynolds S; Shmulevich I; Thorsson V; Zhang W; Akbani R; Broom BM; Ju Z; Li J; Liang H; Ling S; Lu Y; Mills GB; Ng KS; Ryan M; Wang J, 2018, 'A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers', Cancer Cell, vol. 33, pp. 690 - 705.e9, http://dx.doi.org/10.1016/j.ccell.2018.03.014
Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, vol. 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067
Corley S; MacKenzie K; Beverdam A; Roddam LF; Wilkins , 2017, 'Differentially expressed genes from RNA-Seq and functional enrichment results are affected by the choice of single-end versus paired-end reads and stranded versus non-stranded protocols.', BMC Genomics, vol. 18, http://dx.doi.org/10.1186/s12864-017-3797-0
Unnikrishnan A; Guan YF; Huang Y; Beck D; Thoms JAI; Peirs S; Knezevic K; Ma S; De Walle IV; De Jong IDE; Ali Z; Zhong L; Raftery MJ; Taghon T; Larsson J; MacKenzie KL; Van Vlierberghe P; Wong JWH; Pimanda JE, 2016, 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network', Nucleic Acids Research, vol. 44, pp. 10644 - 10661, http://dx.doi.org/10.1093/nar/gkw804
Arndt GM; MacKenzie KL, 2016, 'New prospects for targeting telomerase beyond the telomere', Nature Reviews Cancer, vol. 16, pp. 508 - 524, http://dx.doi.org/10.1038/nrc.2016.55
Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN; Thomas SR; Lock RB; MacKenzie KL; Bushweller JH; Wong JWH; Pimanda JE, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, vol. 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55
O'Brien R; Tran SL; Maritz MF; Liu B; Kong CF; Purgato S; Yang C; Murray J; Russell AJ; Flemming CL; von Jonquieres G; Pickett HA; London WB; Haber M; Gunaratne PH; Norris MD; Perini G; Fletcher JI; MacKenzie KL, 2016, 'MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin', Cancer Research, vol. 76, pp. 3604 - 3617, http://dx.doi.org/10.1158/0008-5472.CAN-15-0879
Pasquier E; André N; Street J; Chougule A; Rekhi B; Ghosh J; Philip DSJ; Meurer M; MacKenzie KL; Kavallaris M; Banavali SD, 2016, 'Effective Management of Advanced Angiosarcoma by the Synergistic Combination of Propranolol and Vinblastine-based Metronomic Chemotherapy: A Bench to Bedside Study', EBioMedicine, vol. 6, pp. 87 - 95, http://dx.doi.org/10.1016/j.ebiom.2016.02.026
El-Hoss J; Jing D; Evans K; Toscan C; Xie J; Lee H; Taylor RA; Lawrence MG; Risbridger GP; MacKenzie KL; Sutton R; Lock RB, 2016, 'A single nucleotide polymorphism genotyping platform for the authentication of patient derived xenografts', Oncotarget, vol. 7, pp. 60475 - 60490, http://dx.doi.org/10.18632/oncotarget.11125
Yaswen P; MacKenzie KL; Keith WN; Hentosh P; Rodier F; Zhu J; Firestone GL; Matheu A; Carnero A; Bilsland A; Sundin T; Honoki K; Fujii H; Georgakilas AG; Amedei A; Amin A; Helferich B; Boosani CS; Guha G; Ciriolo MR; Chen S; Mohammed SI; Azmi AS; Bhakta D; Halicka D; Niccolai E; Aquilano K; Ashraf SS; Nowsheen S; Yang X, 2015, 'Therapeutic targeting of replicative immortality', Seminars in Cancer Biology, vol. 35, pp. S104 - S128, http://dx.doi.org/10.1016/j.semcancer.2015.03.007
Coombes JD; Schevzov G; Kan CY; Petti C; Maritz MF; Whittaker S; Mackenzie KL; Gunning PW, 2015, 'Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout', Cellular and Molecular Biology Letters, vol. 20, pp. 626 - 646, http://dx.doi.org/10.1515/cmble-2015-0037
Sun Y; Bell JL; Carter D; Gherardi S; Poulos RC; Milazzo G; Wong JWH; Al-Awar R; Tee AE; Liu PY; Liu B; Atmadibrata B; Wong M; Trahair T; Zhao Q; Shohet JM; Haupt Y; Schulte JH; Brown PJ; Arrowsmith CH; Vedadi M; MacKenzie KL; Hüttelmaier S; Perini G; Marshall GM; Braithwaite A; Liu T, 2015, 'WDR5 supports an N-myc transcriptional complex that drives a protumorigenic gene expression signature in neuroblastoma', Cancer Research, vol. 75, pp. 5143 - 5154, http://dx.doi.org/10.1158/0008-5472.CAN-15-0423
Tursky ML; Beck D; Thoms JAI; Huang Y; Kumari A; Unnikrishnan A; Knezevic K; Evans K; Richards LA; Lee E; Morris J; Goldberg L; Izraeli S; Wong JWH; Olivier J; Lock RB; MacKenzie KL; Pimanda JE, 2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias', Leukemia, vol. 29, pp. 819 - 827, http://dx.doi.org/10.1038/leu.2014.299
Davies C; Hogarth LA; Mackenzie KL; Hall AG; Lock RB, 2015, 'P21WAF1 modulates drug-induced apoptosis and cell cycle arrest in B-cell precursor acute lymphoblastic leukemia', Cell Cycle, vol. 14, pp. 3602 - 3612, http://dx.doi.org/10.1080/15384101.2015.1100774
Block KI; Gyllenhaal C; Lowe L; Amedei A; Ruhul Amin ARM; Amin A; Aquilano K; Arbiser J; Arreola A; Arzumanyan A; Salman Ashraf S; Azmi AS; Benencia F; Bhakta D; Bilsland A; Bishayee A; Blain SW; Block PB; Boosani CS; Carey TE; Carnero A; Carotenuto M; Casey SC; Chakrabarti M; Chaturvedi R; Chen GZ; Chen H; Chen S; Chen YC; Choi BK; Ciriolo MR; Coley HM; Collins AR; Connell M; Crawford S; Curran CS; Dabrosin C; Damia G; Dasgupta S; DeBerardinis RJ; Decker WK; Dhawan P; Diehl AME; Dong JT; Dou QP; Drewa JE; Elkord E; El-Rayes B; Feitelson MA; Felsheru DW; Ferguson LR; Fimognari C; Firestone GL; Frezza C; Fujii H; Fuster MM; Generali D; Georgakilas AG; Gieseler F; Gilbertson M; Green MF; Grue B; Guhal G; Halicka D; Helferich WG; Heneberg P; Hentosh P; Hirschey MD; Hofseth LJ; Holcombe RF; Honoki K; Hsu HY; Huang GS; Jensen LD; Jiang WG; Jones LW; Karpowicz PA; Keith WN; Kerkar SP; Khan GN; Khatami M; Ko YH; Kucuk O; Kulathinal RJ; Kumar NB; Kwon BS; Leb A; Leab MA; Lee HY; Lichtor T; Lin LT; Locasale JW; Lokeshwar BL; Longo VD; Lyssiotis CA; MacKenzie KL; Malhotra M; Marino M; Martinez-Chantar ML; Matheu A, 2015, 'Designing a broad-spectrum integrative approach for cancer prevention and treatment', Seminars in Cancer Biology, vol. 35, pp. S276 - S304, http://dx.doi.org/10.1016/j.semcancer.2015.09.007
Jamieson WRAB, 2014, 'A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells', Biochemical Pharmacology, vol. 88, pp. 36 - 45, http://dx.doi.org/10.1016/j.bcp.2013.12.019
Wen V; Mackenzie K, 2013, 'Modeling human endothelial cell transformation in vascular neoplasias', Disease Models & Mechanisms, vol. 6, pp. 1066 - 1079, http://dx.doi.org/10.1242/dmm.012674
Pasquier E; Tuset MP; Street J; Sinnappan SM; Mackenzie KL; Braguer D; Andre N; Kavallaris M, 2013, 'Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells', Angiogenesis, vol. 16, pp. 373 - 386, http://dx.doi.org/10.1007/s10456-012-9321-x
Kan C; Petti C; Bracken L; Maritz M; Xu N; O'Brien R; Yang C; Liu T; Yuan J; Lock RB; Mackenzie KL, 2013, 'Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16(INK4a) protein and confers resistance to oxidative stress', The Journal of Biological Chemistry, vol. 288, pp. 12032 - 12041, http://dx.doi.org/10.1074/jbc.M112.447821
Bolden JE; Shi W; Jankowski K; Kan CY; Cluse LA; Martin BP; Mackenzie KL; Smyth GK; Johnstone RW, 2013, 'HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses', Cell Death & Disease, vol. 4, http://dx.doi.org/10.1038/cddis.2013.9
Kan C; Wen VW; Pasquier E; Jankowski K; Chang M; Richards LA; Kavallaris M; Mackenzie K, 2012, 'Endothelial cell dysfunction and cytoskeletal changes associated with repression of p16(INK4a) during immortalization', Oncogene, vol. 31, pp. 4815 - 4827, http://dx.doi.org/10.1038/onc.2011.645
Markovic A; Mackenzie K; Lock RB, 2012, 'Induction of Vascular Endothelial growth factor secretion by childhood acute lymphoblastic leukemia cells via the FLT-3 signaling pathway', Molecular Cancer Therapeutics, vol. 11, pp. 183 - 193, http://dx.doi.org/10.1158/1535-7163.MCT-11-0503
Marshall GM; Liu PY; Gherardi S; Scarlett CJ; Bedalov A; Xu N; Iraci N; MacKenzie KL; Haber M; Norris MD; Biankin AV; Perini G; Liu T, 2011, 'SIRT1 promotes N-Myc oncogenesis stabilizing N-Myc protein', CANCER RESEARCH, vol. 71, http://dx.doi.org/10.1158/1538-7445.AM2011-3027
Davies C; Hogarth L; Dietrich PA; Bachmann PS; Mackenzie KL; Hall AG; Lock RB, 2011, 'p53-independent epigenetic repression of the p21WAF1 gene in T-cell acute lymphoblastic leukemia', The Journal of Biological Chemistry, vol. 286, pp. 37639 - 37650, http://dx.doi.org/10.1074/jbc.M111.272336
Yuan J; Yang BMP; Zhong Z; Shats I; Milyavsky M; Rotter V; Lock RB; Reddel R; Mackenzie K, 2009, 'Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase', Oncogene, vol. 28, pp. 2678 - 2689, http://dx.doi.org/10.1038/onc.2009.136
Ong V; Liem N; Schmid M; Verrills NM; Papa R; Marshall GM; Mackenzie K; Kavallaris M; Lock RB, 2008, 'A role for altered microtubule polymer levels in vincristine resistance of childhood acute lymphoblastic leukemia xenografts', Journal of Pharmacology and Experimental Therapeutics, vol. 324, pp. 434 - 442, http://dx.doi.org/10.1124/jpet.107.128926
Markovic A; Mackenzie KL; Lock RB, 2007, 'Induction of vascular endothelial growth factor secretion in acute leukemia cells via the FLT-3 signaling pathway', MOLECULAR CANCER THERAPEUTICS, vol. 6, pp. 3344S - 3344S, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000251969000042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Schuller C; Jankowski K; Mackenzie K, 2007, 'Telomere length of cord blood-derived CD34+ progenitors predicts erythroid proliferative potential', Leukemia, vol. 21, pp. 983 - 991
Xue C; Haber M; Flemming C; Marshall GM; Lock RB; Mackenzie K; Norris MD; Gurova K; Gudkov A, 2007, 'p53 determines multidrug sensitivity of childhood neuroblastoma.', Cancer research, vol. 67, pp. 10351 - 10360, http://dx.doi.org/10.1158/0008-5472.CAN-06-4345
Perryman LA; Blair JM; Kingsley EA; Szymanska B; Ow KT; Wen VW; MacKenzie KL; Vermeulen PB; Jackson P; Russell PJ, 2006, 'Over-expression of p53 mutants in LNCaP cells alters tumor growth and angiogenesis in vivo', Biochemical and Biophysical Research Communications, vol. 345, pp. 1207 - 1214, http://dx.doi.org/10.1016/j.bbrc.2006.05.020
Perryman LA; Blair JM; Kingsley EA; Ow KT; Wen VW; Mackenzie K; Vermeulen P; Jackson P; Russell PJ; Szymanska B, 2006, 'Over-expression of specific p53 mutants in LNCaP prostate cancer cells alters tumor growth and angiogenesis in vivo', Biochemical and Biophysical Research Communications, vol. 345, pp. 1207 - 1214
Wen VW; Wu K; Baksh S; Hinselwood RA; Lock RB; Clark SJ; Moore MA; Mackenzie K, 2006, 'Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53 competent immortal endothelial cells', Cancer research, vol. 66, pp. 10691 - 10700, http://dx.doi.org/10.1158/0008-5472.CAN-06-0979
Feugier P; Li N; Jo D; Shieh JH; Mackenzie K; Lesesve JF; Latger-Cannard V; Bensoussan D; Crystal RG; Rafii S; Stoltz JF; Moore MA, 2006, 'Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro', Stem Cells and Development, vol. 14, pp. 505 - 516, http://dx.doi.org/10.1089/scd.2005.14.505
Markovic A; Mackenzie K; Lock RB, 2005, 'FLT-3: a new focus in the understanding of acute leukemia', International Journal of Biochemistry and Cell Biology, vol. 37, pp. 1168 - 1172, http://dx.doi.org/10.1016/j.biocel.2004.12.005
Bachmann PS; Gorman R; MacKenzie KL; Lutze-Mann L; Lock RB, 2005, 'Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor', Blood, vol. 105, pp. 2519 - 2526, http://dx.doi.org/10.1182/blood-2004-05-2023
Liem N; Papa R; Milross CG; Schmid M; Tajbakhsh M; Choi S; Ramirez C; Rice AM; Haber M; Norris MD; Lock RB, 2004, 'Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies', Blood, vol. 103, pp. 3905 - 3914, http://dx.doi.org/10.1182/blood-2003-08-2911
Shen SC; Dolnikov A; Passioura TJ; Millington M; Wotherspoon S; Rice AM; Mackenzie K; Symonds GP, 2004, 'Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid proliferation both in vitro and in the NOd/SCID mouse.', Experimental Hematology, vol. 32, pp. 852 - 860, http://dx.doi.org/10.1016/j.exphem.2004.06.001
Taylor LM; James A; Schuller C; Brce J; Lock RB; Mackenzie K, 2004, 'Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human M3C5 fibroblasts that overcome a telomere-independent crisis during immortalization', The Journal of Biological Chemistry, vol. 279, pp. 43634 - 43635, http://dx.doi.org/10.1074/jbc.M402388200
Mackenzie KL; Franco S; Naiyer AJ; May C; Sadelain M; Rafii S; Moore MAS, 2002, 'Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras', Oncogene, vol. 21, pp. 4200 - 4211, http://dx.doi.org/10.1038/sj.onc.1205425
Feugier P; Deog YJ; Jae HS; Mackenzie KL; Rafii S; Crystal RG; Moore MAS, 2002, 'Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand', Journal of Hematotherapy and Stem Cell Research, vol. 11, pp. 127 - 138, http://dx.doi.org/10.1089/152581602753448595
Mulloy JC; Cammenga J; MacKenzie KL; Berguido FJ; Moore MAS; Nimer SD, 2002, 'The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells', Blood, vol. 99, pp. 15 - 23, http://dx.doi.org/10.1182/blood.V99.1.15
Feugier P; Jo DY; Shieh JH; Mackenzie K; Rafii S; Crystal RG; Moore MA, 2002, 'Cord blood CD34+ cells co-cultured with HUVEC expressing Kit-Ligand, Flt-3L and Thrombopoietin expands progenitors, week 5 CAFC and NOD-SCID repopulating cells', Journal of Hematotherapy and Stem Cell Research, vol. 11, pp. 127 - 138
Mulloy JC; Cammenga J; Mackenzie K; Berguido F; Moore MA; Nimer S, 2002, 'The AML1-ETO fusion promotes the expansion of human hematopoietic stem cells', Blood, vol. 99, pp. 15 - 23
MacKenzie K; Takebe N; Chen L-C; MacKenzie KL; Bertino JR; Moore MAS, 2002, 'Methotrexate selection of long-term culture initiating cells following transduction of CD34+ cells with a retrovirus containing a mutated human dihydrofolate reductase gene', Cancer Gene Ther, vol. 9, pp. 308 - 320
Takebe N; Xu LC; Mackenzie K; Bertino JR; Moore MA, 2002, 'Methotrexate selection of long term culture initiating cells following transduction of CD34+ cells with a retrovirus containing a mulated human dihydrofolate gene', Cancer Gene Therapy, vol. 9, pp. 308 - 320, http://dx.doi.org/10.1038/sj.cgt.7700443
Boklan J; Nanjangud G; Mackenzie K; May CN; Sadelain M; Moore MA, 2002, 'Limited Proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibroblasts', Cancer research, vol. 62, pp. 2104 - 2114
Mackenzie K; Franco S; Naiyer AJ; May CN; Sadelain M; Rafii S; Moore MA, 2002, 'Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras', Oncogene, vol. 21, pp. 4200 - 4211, http://dx.doi.org/10.1038/sj/onc/1205425
Franco S; MacKenzie KL; Dias S; Alvarez S; Rafii S; Moore MAS, 2001, 'Clonal variation in phenotype and lifespan of human embryonic fibroblasts (MRC-5) transduced with the catalytic component of telomerase (hTERT)', Exp Cell Res, vol. 268, pp. 14 - 25, http://dx.doi.org/10.1006/excr.2001.5264
Feugier P; Shieh JH; Jo DY; MacKenzie KL; Rafii S; Crystal RG; Moore MAS, 2000, 'Cord blood cd34+ cells co-cultured with huvec transfected with adenovirus expressing kl, fl and tpo leads to expansion of progenitors, week-5 cafc and nod-scid repopulating cells', Blood, vol. 96
Feugier P; Shieh JH; Jo DY; MacKenzie KL; Rafii S; Crystal RG; Moore MAS, 2000, 'Long-term expansion of hematopoietic cells in CD34+cells co-cultures with murine osteopetrotic stromal cells, OP-9, transfected with adenovirus expressing thrombopoietin.', BLOOD, vol. 96, pp. 666A - 666A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000165256102863&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Feugier P; Shieh JH; Jo DY; MacKenzie KL; Rafii S; Crystal RG; Moore MAS, 2000, 'Cord blood CD34+cells co-cultured with HUVEC transfected with adenovirus expressing KL, FL and Tpo leads to expansion of progenitors, week-5 CAFC and NOD-SCID repopulating cells.', BLOOD, vol. 96, pp. 281A - 281A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000165256101207&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Mulloy JC; Cammenga J; MacKenzie KL; Moore MAS; Nimer SD, 2000, 'AML1/ETO promotes the expansion of early human hematopoietic stem cells.', BLOOD, vol. 96, pp. 572A - 572A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000165256102459&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Engelhardt M; Mackenzie K; Drullinsky P; Silver RT; Moore MAS, 2000, 'Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex vivo culture', Cancer Research, vol. 60, pp. 610 - 617
Engelhardt M; MacKenzie K; Drullinsky P; Moore MAS, 2000, 'Telomerase activity in acute and chronic leukemia, pre- and post- ex vivo expansion', Cancer Research, vol. 60, pp. 610 - 617
MacKenzie K; Franco S; May C; Tan C; Sadelain MA; Moore MAS, 2000, 'Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation', Exp Cell Res, vol. 259, pp. 336 - 350, http://dx.doi.org/10.1006/excr.2000.4982
MacKenzie K; Hackett NR; Crystal RG; Moore MAS, 2000, 'Adenoviral vector-mediated gene transfer to primitive human hematopoietic progenitor cells: assessment of transduction and toxicity in long-term culture', Blood, vol. 96, pp. 100 - 108
MacKenzie KL; Boklan J; Franco S; Feugier P; Moore MAS, 1999, 'Overexpression of the catalytic subunit of telomerase in human hematopoietic progenitor cells.', BLOOD, vol. 94, pp. 253A - 253A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083790301172&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Franco S; MacKenzie KL; Tan CW; May C; Sadelain M; Moore MAS, 1999, 'Expression of telomerase after retroviral transduction increases lifespan of primary human fibroblasts', PEDIATRIC RESEARCH, vol. 45, pp. 146A - 146A, http://dx.doi.org/10.1203/00006450-199904020-00868
Moore MAS; MacKenzie KL, 1999, 'Optimizing conditions for gene transfer into human hematopoietic cells', Progress in Experimental Tumor Research, vol. 36, pp. 20 - 49, http://dx.doi.org/10.1159/000061987
Mackenzie K; Dolnikov A; Millington M; Yi S; Symonds GP, 1999, 'Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice', Blood, vol. 93, pp. 2043 - 2056
MacKenzie KL; Franco S; Naiyer AJ; May C; Tan C; Peichev MA; Sadelain M; Rafii S; Moore MAS, 1998, 'Extended life span of human bone marrow endothelial cells transfected with human telomerase reverse transcriptase.', BLOOD, vol. 92, pp. 704A - 704A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000077121302881&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
MacKenzie KL; Hackett NR; Crystal RG; Moore MAS, 1998, 'Adenoviral vector-mediated gene transfer to primitive human hematopoietic cells; Quantification of transduced long-term culture-initiating cells (LTC-IC).', BLOOD, vol. 92, pp. 469A - 469A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000077121301923&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Dolnikov A; Yi S; Millington M; Mackenzie K; Symonds GP, 1998, 'V-myc in a simple, single gene retroviral vector causes rapid induction of leukemia and concomitant apoptosis following bone marrow transplantation', Leukemia, vol. 12, pp. 542 - 553, http://dx.doi.org/10.1038/sj.leu.2400968
MacKenzie KL; Frey BM; Hackett NR; Crystal RG; Moore MAS, 1997, 'Functional analysis of hematopoietic progenitor cells, transduced by an adenoviral vector expressing green fluorescent protein.', BLOOD, vol. 90, pp. 4616 - 4616, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997YG42501925&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Shounan Y; MacKenzie K; Dolnikov A; Miller M; Symonds G, 1997, 'Myeloproliferative disease and myelodysplastic syndrome induced by transplantation of bone marrow cells expressing mutant p53', Leukemia, vol. 11, pp. 1641 - 1649, http://dx.doi.org/10.1038/sj.leu.2400782
Shounan Y; Dolnikov A; MacKenzie KL; Miller M; Chan YY; Symonds G, 1996, 'Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis', Leukemia, vol. 10, pp. 1619 - 1628
Yi S; Dolnikov A; MacKenzie KL; Miller M; Symonds G, 1995, 'Mutant p53 transformation of murine bone marrow-derived hematopoietic cells.', BLOOD, vol. 86, pp. 4021 - 4021, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TH91004021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
MacKenzie K; Bonham L; Symonds G, 1994, 'An internal deletion enhances the transcriptional activity of a recombinant retrovirus in haematopoietic cells in vivo', J Virol, vol. 68, pp. 6924 - 6932
Bonham L; MacKenzie K; Wood S; Rowe PB; Symonds G, 1992, 'Both myeloproliferative disease and leukemia are induced by transplantation of bone marrow cells expressing v-myc', Oncogene, vol. 7, pp. 2219 - 2229
Sullivan J; Trejaut J; Guinan J; McKenzie K; Doran T; Honeyman M; Chapman J, 1989, 'Class II DNA polymorphisms and renal allograft outcome', Transplantation Proceedings, vol. 21, pp. 667
Sullivan J; Trejaut J; Guinan J; MacKenzie KL; Doran T; Honeyman M; Chapman J, 1989, 'Class II DNA polymorphisms and renal allograft outcome', Transpl Proc, vol. 21, pp. 667
Conference Papers
Unnikrishnan A; Papaemmanuil E; Beck D; Kumari A, 2015, 'An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML', in An Integrative Genomics Approach Uncovers the Basis of Resistance to, AMER SOC HEMATOLOGY, USA, presented at ASH Annual Meeting, USA, 05 December 2015 - 08 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019002147&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Unnikrishnan A; Beck D; Verma A; Richards LA; Thoms JAI; Kumari A; Galbraith S; Kulasekararaj A; Tobiasson M; Woll PS; Pellagatti A; Papaemmanuil E; Wilson SR; Lindeman R; Campbell PJ; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; MacKenzie KL; Wong JWH; Pimanda JE, 2014, 'Identification of a Prognostic Gene Expression Signature for AZA Response in MDS and CMML Patients', in BLOOD, AMER SOC HEMATOLOGY, San Francisco, CA, presented at 56th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, 06 December 2014 - 09 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349243501166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Kumari A; Richards LA; Jonquieres G; Knezevic K; O'Brien R; Napier CE; Marks-Bluth J; Pickett H; Pimanda JE; MacKenzie KL, 2012, 'Dyskerin Is Upregulated During Erythroid Differentiation of Human Hematopoietic Progenitor Cells and Hyperactivates Telomerase in Erythroid Precursor Cells', in BLOOD, AMER SOC HEMATOLOGY, Atlanta, GA, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta, GA, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.980.980
Wen VW; Wu K; Bakshs S; Moore MAS; Mackenzie KL, 2006, 'Telomere-driven karyotypic complexity concurs with p16INK4a repression in hTERT-immortalized endothelial cells', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454608804007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Symonds GP; Dolnikov A; Mackenzie K; Millington M; Yi S, 1997, 'Tumor suppressor gene transfer as a therapeutic stratergy for hematopoietic malignancies', in Cancer genetics and tumor supprressor genes conference, Cancer genetics and tumor supprressor genes conference, Frederick, Maryland, pp. 71 - 71, presented at Cancer genetics and tumor supprressor genes conference, Frederick, Maryland, 12 June 1997 - 16 June 1997
Dolnikov A; Mackenzie K; Millington M; Yi S; Symonds GP, 1997, 'Tumor suppressor gene transfer as a therapeutic stratergy for hematopoietic malignancies', in Australian Society of Medical research, Australian Society of Medical research, Garvan Institute, Sydney, pp. P-30, presented at Australian Society of Medical research, Garvan Institute, Sydney
Conference Presentations
Sun Y; Liu PY; Scarlett CJ; Malyukova A; Liu B; Marshall GM; MacKenzie KL; Biankin AV; Liu T, 2014, 'Histone deacetylase 5 blocks neuroblastoma cell differentiation by forming a protein complex with N-Myc and repressing target gene transcription', in INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SPANDIDOS PUBL LTD, Vol. 34, pp. S132 - S132, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341276000510&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Conference Abstracts
Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky M; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'INTEGRATIVE GENOMICS IDENTIFIES THE MOLECULAR BASIS OF RESISTANCE TO AZACITIDINE THERAPY IN MYELODYSPLASTIC SYNDROMES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, Copenhagen, DENMARK, Vol. 101, pp. 157 - 158, presented at 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, 09 June 2016 - 12 June 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600349&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Maritz M; Cowley MJ; Kaplan W; Kavallaris M; MacKenzie KL, 2012, 'Repression of Essential Telomerase Components Mediates Anti-proliferative Effects in Isogenic Immortal and Tumorigenic Cells, but not Normal Cells', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Barcelona, SPAIN, Vol. 48, pp. S79 - S80, presented at 22nd Biennial Congress of the European-Association-for-Cancer-Research, Barcelona, SPAIN, 07 July 2012 - 10 July 2012, http://dx.doi.org/10.1016/S0959-8049(12)71017-1