Dr Eddy Pasquier

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Contact Category:

Conjoint

Discipline:

Paediatrics

Dr Eddy Pasquier is a Senior Research Officer in the Tumour Biology and Targeting Program of the Children’s Cancer Institute Australia (CCIA) and a Lecturer with the School of Women’s and Children’s Health. He is the recipient of a 2011 NSW Young Tall Poppy award for his community outreach initiatives and his research into how blood vessels grown in tumours, and in 2010 won a Faculty of Medicine Dean’s Rising Star Award for his outstanding contribution to research.

Research Interests:
Angiogenesis is defined as the formation of new blood vessels from pre-existing ones. It is crucial for organ growth during development but also throughout adult life to repair wounded tissues. Furthermore, an imbalance in this process directly contributes to numerous pathologies such as cancer, diabetes, age-related macular degeneration, ischemic disorders and rheumatoid arthritis. The multi-step and complex process leading to the formation of a new vascular network relies on the activation of vascular endothelial cells followed by their proliferation, migration and morphological differentiation into capillary tubes. Advanced medical and fundamental research is vital to fully unravel the mechanisms involved in angiogenesis and identify new therapeutic targets for angiogenesis-related disorders.

Broad Research Areas:
Cancer, Paediatrics / Child Health, Pharmacology, Cell Biology and Gene Regulation, Proteomics

Specific Research Keywords:
Angiogenesis, Cytoskeleton, Chemotherapy, Experimental Therapeutics, Translational Research

Phone:

9385 1557

Email:

epasquier@unsw.edu.au

University role:

Conjoint Lecturer

Research

Field of Research (FOR) Tag:

Oncology and Carcinogenesis

Chemotherapy

Cancer Cell Biology

Publications related to this Person

Book Chapters

Kavallaris M; Pasquier E; Andre N, 2014, 'Metronomic Chemotherapy regimens using microtubule-targeting agents:mechanisms of action, pre-clinical activity and future developments.', in Bocci G; Francia G (ed.), Metronomic Chemotherapy, Springer, pp. 69 - 90, http://dx.doi.org/10.1007/978-3-662-43604-2_5

Journal articles

Pasquier E, 2015, 'Maintenance chemotherapy exerts metronomic-like antiangiogenic effects in children with ALL', Oncotarget

Brandl MB; Pasquier E; Li F; Beck D; Zhang S; Zhao H; Kavallaris M; Wong STC, 2014, 'Computational analysis of image-based drug profiling predicts synergistic drug combinations: Applications in triple-negative breast cancer', Molecular Oncology, vol. 8, pp. 1548 - 1560, http://dx.doi.org/10.1016/j.molonc.2014.06.007

Eiffe E; Pasquier E; Kavallaris M; Herbert C; Black DSC; Kumar N, 2014, 'Synthesis, anti-cancer and anti-inflammatory activity of novel 2-substituted isoflavenes', Bioorganic and Medicinal Chemistry, vol. 22, pp. 5182 - 5193, http://dx.doi.org/10.1016/j.bmc.2014.08.010

Tee EL; Ling D; Nelson C; Atmadibrata B; Dinger M; XU N; Mizukami T; Liu PY; Liu B; Cheung B; Pasquier E; Haber M; Norris MD; Suzuki T; Marshall GM; Liu T, 2014, 'The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1', Oncotarget, vol. 5, pp. 1793 - 1804, http://dx.doi.org/10.18632/oncotarget.1785

McGuire MF; Enderling H; Wallace DI; Batra J; Jordan M; Kumar S; Panetta JC; Pasquier E, 2013, 'Formalizing an integrative, multidisciplinary cancer therapy discovery workflow', Cancer Research, vol. 73, pp. 6111 - 6117, http://dx.doi.org/10.1158/0008-5472.CAN-13-0310

Pasquier E; Trahair T; Kavallaris M; Andre N, 2013, 'Reply: Comment on 'beta-blockers increase response to chemotherapy via direct anti-tumour and anti-angiogenic mechanisms in neuroblastoma'-β- blockers are potent anti-angiogenic and chemo-sensitising agents, rather than cytotoxic drugs', British Journal of Cancer, vol. 109, pp. 2024 - 2025, http://dx.doi.org/10.1038/bjc.2013.498

Pasquier E; Street J; Pouchy C; Carre M; Gifford AJ; Murray J; Norris MD; Trahair T; Andre N; Kavallaris M, 2013, 'B-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma', British Journal of Cancer, vol. 108, pp. 2485 - 2494, http://dx.doi.org/10.1038/bjc.2013.205

André N; Pasquier E, 2013, 'Metronomics in low and middle income countries: India showing the way!', Indian Journal of Cancer, vol. 50, pp. 112 - 114, http://dx.doi.org/10.4103/0019-509X.117026

André N; Banavali S; Snihur Y; Pasquier E, 2013, 'Has the time come for metronomics in low-income and middle-income countries?', The Lancet Oncology, vol. 14, http://dx.doi.org/10.1016/S1470-2045(13)70056-1

Pasquier E; Tuset MP; Street J; Sinnappan SM; Mackenzie KL; Braguer D; Andre N; Kavallaris M, 2013, 'Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells', Angiogenesis, vol. 16, pp. 373 - 386, http://dx.doi.org/10.1007/s10456-012-9321-x

Yee EMH; Pasquier E; Iskander GM; Wood K; Black D; Kumar NSS, 2013, 'Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents', Bioorganic and Medicinal Chemistry, vol. 21, pp. 1652 - 1660, http://dx.doi.org/10.1016/j.bmc.2013.01.059

Andre N; Guercio B; Pasquier E, 2013, 'Investment in cancer studies in countries of low and middle income', The Lancet, vol. 382, pp. 684 - 684, http://dx.doi.org/10.1016/s0140-6736(13)61777-8

Traore F; Togo B; Pasquier E; Dembélé A; André N, 2013, 'Preliminary evaluation of children treated with metronomic chemotherapy and valproic acid in a low-income country: Metro-Mali-02', Indian Journal of Cancer, vol. 50, pp. 250 - 250, http://dx.doi.org/10.4103/0019-509X.118741

Kan C; Wen VW; Pasquier E; Jankowski K; Chang M; Richards LA; Kavallaris M; Mackenzie K, 2012, 'Endothelial cell dysfunction and cytoskeletal changes associated with repression of p16(INK4a) during immortalization', Oncogene, vol. 31, pp. 4815 - 4827, http://dx.doi.org/10.1038/onc.2011.645

Andre N; Pasquier E; Kamen B, 2012, 'Can targeted therapy be Successful without metronomic scheduling?', Current Topics in Medicinal Chemistry, vol. 12, pp. 1639 - 1642, http://dx.doi.org/10.2174/156802612803531432

Shum M; Pasquier E; Po'uha ST; O'Neill GM; Chaponnier C; Gunning PW; Kavallaris M, 2011, 'γ-Actin regulates cell migration and modulates the ROCK signaling pathway', The FASEB Journal, vol. 25, pp. 4423 - 4433, http://dx.doi.org/10.1096/fj.11-185447

Andre N; Abed S; Orbach D; Alla CA; Padovani L; Pasquier E; Gentet JC; Verschuur A, 2011, 'Pilot study of a pediatric metronomic 4-drug regimen', Oncotarget, vol. 2, pp. 960 - 965, http://dx.doi.org/10.18632/oncotarget.358

Pasquier E; Ciccolini J; Carre M; Giacometti S; Fanciullino R; Pouchy C; Montero MP; Serdjebi C; Kavallaris M; Andre N, 2011, 'Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment.', Oncotarget, vol. 2, pp. 797 - 809, http://dx.doi.org/10.18632/oncotarget.343

Pasquier E; Kieran MW; Sterba J; Shaked Y; Baruchel S; Oberlin O; Kivivuori MS; Peyrl A; Diawarra M; Casanova M; Zacharoulis S; Vassal G; Berthold F; Verschuur A; Andre N, 2011, 'Moving forward with metronomic chemotherapy: Meeting report of the 2nd International Workshop on Metronomic and Anti-Angiogenic Chemotherapy in Paediatric Oncology', Translational Oncology, vol. 4, pp. 189 - 197, http://dx.doi.org/10.1593/tlo.11124

Andre N; Padovani L; Pasquier E, 2011, 'Metronomic scheduling of anticancer treatment: the next generation of multitarget therapy?', Future Oncology, vol. 7, pp. 385 - 394, http://dx.doi.org/10.2217/FON.11.11

Andre N; Pasquier E; Gentet JC; Kamen BA, 2011, 'Looking at the Seemingly Contradictory Role of Vinblastine in Anaplastic Large-Cell Lymphoma From a Metronomic Perspective', Journal of Clinical Oncology, vol. 29, pp. E90 - E91, http://dx.doi.org/10.1200/JCO.2010.32.2883

Fousseyni T; Diawara M; Pasquier E; Andre N, 2011, 'Children treated with metronomic chemotherapy in a low-income country: METRO-MALI-01', Journal of Pediatric Hematology and Oncology, vol. 33, pp. 31 - 34, http://dx.doi.org/10.1097/MPH.0b013e3182018ab8

Pasquier E; Andre N, 2010, 'Hot topic: New Therapeutic Advances and Perspectives in Tumour Angiogenesis', Current Cancer Drug Targets, vol. 10, pp. 877 - 878

Pasquier E; Sinnappan S; Munoz M; Kavallaris M, 2010, 'ENMD-1198, a New Analogue of 2-Methoxyestradiol, Displays Both Antiangiogenic and Vascular-Disrupting Properties', Molecular Cancer Therapeutics, vol. 9, pp. 1408 - 1418, http://dx.doi.org/10.1158/1535-7163.MCT-09-0894

Pasquier E; Dias S, 2010, 'Endothelial Progenitor Cells: Hope Beyond Controversy', Current Cancer Drug Targets, vol. 10, pp. 914 - 921

Pasquier E; Kavallaris M; Andre N, 2010, 'Metronomic chemotherapy: new rationale for new directions', Nature Reviews Clinical Oncology, vol. 7, pp. 455 - 465, http://dx.doi.org/10.1038/nrclinonc.2010.82

Rome A; Andre N; Scavarda D; Gentet J; De paula AM; Padovani L; Pasquier E, 2009, 'Metronomic Chemotherapy-Induced Bilateral Subdural Hematoma in a Child With Meningeal Carcinomatosis', Pediatric Blood and Cancer, vol. 53, pp. 246 - 247, http://dx.doi.org/10.1002/pbc.22022

Andre N; Pasquier E; Verschuur A; Sterba J; Gentet JC; Rossler J, 2009, 'Metronomic chemotherapy in pediatric oncology: Hype or hope?', Archives de Pediatrie, vol. 16, pp. 1158 - 1165, http://dx.doi.org/10.1016/j.arcped.2009.03.019

Andre N; Pasquier E, 2009, 'For cancer, seek and destroy or live and let live?', Nature, vol. 460, pp. 324 - 324, http://dx.doi.org/10.1038/460324c

Pasquier E; Kavallaris M, 2008, 'Microtubules: A dynamic target in cancer therapy', IUBMB Life, vol. 60, pp. 165 - 170, http://dx.doi.org/10.1002/iub.25

Andre N; Rome A; Coze C; Padovani L; Pasquier E; Camoin L; Gentet J, 2008, 'Metronomic etoposide/cyclophosphamade/celecoxib regimen given to children and adolescents with refractory cancer: a preliminary monocentric study.', Clinical Therapeutics, vol. 30, pp. 1336 - 1340, http://dx.doi.org/10.1016/S0149-2918(08)80059-8

Gan PP; Pasquier E; Kavallaris M, 2007, 'Class III beta-tubulin mediates sensitivity to chemotherapeutic drugs in non-small cell lung cancer', Cancer research, vol. 67, pp. 9356 - 9363, http://dx.doi.org/10.1158/0008-5472.CAN-07-0509

Pasquier E; Andre N; Braguer D, 2007, 'Targeting microtubules to inhibit angiogenesis and disrupt tumour vasculature: Implications for cancer treatment', Current Cancer Drug Targets, vol. 7, pp. 566 - 581, http://dx.doi.org/10.2174/156800907781662266

School of Women's and Children's Health

Dr Eddy Pasquier

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